Larkana or Larkano  is fourth largest city in the north-western part of Sindh province, Pakistan. It is located within Larkana District. The historical name of Larkana until 1901 was Chandka. Larkana is located on the south bank of the Ghar canal, about 40-miles south of the town Shikarpur, and 36 miles north-east of Mehar.

The majority of the population of both the city & the district of Larkana speak the native Sindhi language. English and Urdu are also widely understood. saraiki, Balochi, Punjabi and Brahvi are also spoken in various pockets of the city.

It is surrounded by fertile land, where many varieties of fruits and vegetables are cultivated. These include potatoes, melons, olives, oranges, peas, carrots, cucumber, mangoes and guava. Some 10 km from the city, sugarcane is cultivated and processed, since 1990, at a Sugar Mill near the town of Nau Dero.

Larkana Railway Station is located in the center of this city. It connects the city of Larkana to the rest of Sindh and Pakistan via rail, & assists in the transport of agricultural produce to the larger cities such as Karachi. Moenjodaro Airport is located near Mohen-jo-daro, 28 km away to the south of the city of Larkana, 5 kilometers away from Dokri. The main users of the airport are Pakistan International Airlines, the country’s national flag carrier. The outdated infrastructure of the airport prevents the use of large, advanced aircraft, with the PIA largely using Fokker airplanes for flights. Larkana is connected via bus to most major Pakistani cities such as Karachi, Islamabad, and Quetta.